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University of Toledo
The Collage of Medicine
1502
Chronic Kidney Disease, Cardiovascular Disease, Metabolic Syndrom, Endocrine Disease
"Cardiotonic Steroids and the Sodium Trade Balance: New Insights into Trade-Off Mechanisms Mediated by the Na+/K+-ATPase
FK Khalaf, P Dube, A Mohamed, J Tian, D Malhotra, ST Haller, ...
International journal of molecular sciences 19 (9), 2576 39 2018
Chronic low dose oral exposure to microcystin-LR exacerbates hepatic injury in a murine model of non-alcoholic fatty liver disease
A Lad, RC Su, JD Breidenbach, PM Stemmer, NJ Carruthers, NK Sanchez, ...
Toxins 11 (9), 486 35 2019
Exposure to the harmful algal bloom (HAB) toxin microcystin-LR (MC-LR) prolongs and increases severity of dextran sulfate sodium (DSS)-induced colitis
RC Su, TM Blomquist, AL Kleinhenz, FK Khalaf, P Dube, A Lad, ...
Toxins 11 (6), 371 27 2019
Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na+/K+-ATPase Profibrotic Signaling Pathways
DJ Kennedy, FK Khalaf, B Sheehy, ME Weber, B Agatisa-Boyle, J Conic, ...
International journal of molecular sciences 19 (9), 2566 22 2018
Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma
JX Xie, S Zhang, X Cui, J Zhang, H Yu, FK Khalaf, D Malhotra, ...
Nephrology Dialysis Transplantation 33 (7), 1138-1149 18 2018
A PON for all seasons: comparing paraoxonase enzyme substrates, activity and action including the role of PON3 in health and disease
CJ Mohammed, S Lamichhane, JA Connolly, SM Soehnlen, FK Khalaf, ...
Antioxidants 11 (3), 590 12 2022
Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia
S Zhang, JD Breidenbach, FK Khalaf, PR Dube, CJ Mohammed, A Lad, ...
Journal of the American Heart Association 9 (7), e014072 12 2020
Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na+/K+‐ATPase‐α‐1
FK Khalaf, I Tassavvor, A Mohamed, Y Chen, D Malhotra, Z Xie, J Tian, ...
Journal of the American Heart Association 9 (3), e013933 10 2020
Microcystin-LR aerosol induces inflammatory responses in healthy human primary airway epithelium
JD Breidenbach, BW French, TT Gordon, AL Kleinhenz, FK Khalaf, ...
Environment International 169, 107531 9 2022
Antioxidant therapy significantly attenuates hepatotoxicity following low dose exposure to microcystin-LR in a murine model of diet-induced non-alcoholic fatty liver disease
A Lad, J Hunyadi, J Connolly, JD Breidenbach, FK Khalaf, P Dube, ...
Antioxidants 11 (8), 1625 9 2022
Proinflammatory effects of cardiotonic steroids mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src complex in renal epithelial cells and immune cells
FK Khalaf, P Dube, AL Kleinhenz, D Malhotra, A Gohara, CA Drummond, ...
Hypertension 74 (1), 73-82 7 2019
Paraoxonase-1 regulation of renal inflammation and fibrosis in chronic kidney disease
FK Khalaf, CJ Mohammed, P Dube, JA Connolly, A Lad, UM Ashraf, ...
Antioxidants 11 (5), 900 5 2022
Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages
RC Su, JD Breidenbach, K Alganem, FK Khalaf, BW French, P Dube, ...
International Journal of Molecular Sciences 22 (18), 9939 5 2021
Cardioprotective role for paraoxonase-1 in chronic kidney disease
P Dube, FK Khalaf, A DeRiso, CJ Mohammed, JA Connolly, D Battepati, ...
Biomedicines 10 (9), 2301 4 2022
Dirty jobs: macrophages at the heart of cardiovascular disease
TW Stevens, FK Khalaf, S Soehnlen, P Hegde, K Storm, ...
Biomedicines 10 (7), 1579 4 2022
Getting to the heart and soul of chronic kidney disease
FK Khalaf, P Dube, CJ Mohammed, DJ Kennedy
Journal of the American Heart Association 9 (15), e017427 4 2020
Cardiotonic steroid signaling through Na/K-atpase-A-1 and src kinase enhance functional interactions between immune cells and endo/epithelial cells
FK Khalaf, A Mohamed, A Kleinhenz, E Crawford, J Tian, Z Xie, ...
JOURNAL OF INVESTIGATIVE MEDICINE 66 (4), 859-859 2 2018
Cardiotonic steroid signaling through Na/K-ATPase-alpha-1 and Src kinase enhance immune cell pro-inflammatory response
FK Khalaf, AL Kleinhenz, EL Crawford, J Tian, D Malhotra, ST Haller, ...
Circulation 136 (suppl_1), A17625-A17625 2 2017
Paraoxonases at the Heart of Neurological Disorders
FK Khalaf, J Connolly, B Khatib-Shahidi, A Albehadili, I Tassavvor, ...
International Journal of Molecular Sciences 24 (8), 6881 1 2023
Targeted Disruption of Paraoxonase 3 in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease Increases Renal Cortical Pro-Inflammatory Eicosanoids
CJ Mohammed, FK Khalaf, P Dube, TJ Reid, JA Connolly, ...
Circulation 142 (Suppl_3), A16835-A16835 1 2020
Paraoxonase 3 is Renoprotective in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease
CJ Mohammed, FK Khalaf, P Dube, D Battepati, I Tassavvor, ...
Circulation 140 (Suppl_1), A13721-A13721 1 2019
Novel Model of Oxalate Diet-Induced Chronic Kidney Disease in Dahl-Salt-Sensitive Rats
P Dube, V Aradhyula, A Lad, FK Khalaf, JD Breidenbach, E Kashaboina, ...
International Journal of Molecular Sciences 24 (12), 10062 2023
Oxalate Diet Induced Chronic Kidney Disease in Dahl-Salt-Sensitive Rats Induces Uremic Cardiomyopathy
P Dube
Translation: The University of Toledo Journal of Medical Sciences 11 (1) 2023
EVALUATING THE ROLE OF DIFFERENT TYPES OF LASER THERAPY IN BECKERS NEVUS TREATMENT
P Dube, M Albakaa, M Aldhalimi, F Khalaf
JOURNAL OF INVESTIGATIVE MEDICINE 70 (7), 1576-1576 2022
Evaluating the Roles of Different Types of Laser Therapy in Becker’s Nevus Treatment
MK Al-Bakaa, MA Al-Dhalimi, P Dube, FK Khalaf
Journal of Clinical Medicine 11 (14), 4230 2022
Antioxidant Therapy Ameliorates Hepatotoxicity Induced by Microcystin-LR in an Oleic acid-induced Model of Hep3B Cells Mimicking the Diet-induced Mouse Model of Non-alcoholic …
A Lad, J Breuler, P Hegde, F KHALAF, AL KLEINHENZ, T HINDS, ...
Mechanism of Hepatic Injury Susceptibility and Immune Response to Cyanotoxin … 2021
Antioxidant Therapy Significantly Attenuates Hepatotoxicity Following Low Dose Exposure to Microcystin-LR in a Murine Model of Diet-induced Non-alcoholic Fatty Liver Disease
A Lad, J Hunyadi, FK Khalaf, P Dube, J Connolly, D Baliu-Rodriguez, ...
Mechanism of Hepatic Injury Susceptibility and Immune Response to Cyanotoxin … 2021
Renin-Angiotensin Metabolite Profiling via LC-MS/MS Reveals Sex Dependent Differences Induced by High-Salt Diet in Dahl-S Rats
PR Dube, CJ Mohammed, F Khalaf, S Zhang, D Faleel, S Soehnlen, ...
Circulation 144 (Suppl_1), A13442-A13442 2021
Novel Model of Oxalate Diet Induced Chronic Kidney Disease in Dahl-Salt-Sensitive Rats
P Dube, V Aradhyula, J Connolly, F Khalaf, S Soehnlen, A DeRiso, ...
Circulation 144 (Suppl_1), A12660-A12660 2021
MODULATION OF CARDIOTONIC STEROID ACTIVATION OF NA/K-ATPASE-SRC SIGNALING VIA PNAKTIDE DECREASES CARDIAC INFLAMMATION AND FIBROSIS IN A DAHL SALT SENSITIVE MODEL OF CHRONIC …
P Dube, FK Khalaf, M Patel, A DeRiso, B Khatib-Shahidi, CJ Mohammed, ...
JOURNAL OF INVESTIGATIVE MEDICINE 69 (5), 1079-1079 2021
ANTIOXIDANT THERAPY RESTORES HEPATIC PHASE I & PHASE II METABOLIC ENZYMES ALTERED BY EXPOSURE TO MICROCYSTIN-LR IN A MURINE MODEL OF DIET-INDUCED NON-ALCOHOLIC FATTY LIVER DISEASE
AC Lad, J Hunyadi, J Connolly, FK Khalaf, P Dube, S Zhang, A Kleinhenz, ...
JOURNAL OF INVESTIGATIVE MEDICINE 69 (5), 1140-1141 2021
ACTIVATION OF NA/K-ATPASE SIGNALING BY THE ARACHIDONIC ACID METABOLITE 20-HYDROXYEICOSATETRAENOIC ACID
D Faleel, FK Khalaf, S Zhang, P Dube, D Malhotra, ST Haller, DJ Kennedy
JOURNAL OF INVESTIGATIVE MEDICINE 69 (5), 1124-1124 2021
Paraoxanase-1 Modulates Cardiotonic Steroid Induced Cardiac Inflammation and Fibrosis in Dahl Salt Sensitive Model of Chronic Kidney Disease
PR Dube, F Khalaf, M Patel, B Khatibshahidi, A DeRiso, A Lad, ...
Circulation 142 (Suppl_3), A16965-A16965 2020
PARAOXONASE 1 DELETION LEADS TO INCREASES IN THE PRO-INFLAMMATORY EICOSANOID 20-HETE AS WELL AS RENIN-ANGIOTENSIN SYSTEM ACTIVATION IN A DAHL SALT-SENSITIVE RAT MODEL OF …
FK Khalaf, A Lad, CJ Mohammed, P Dube, JA Connolly, AL Kleinhenz, ...
JOURNAL OF INVESTIGATIVE MEDICINE 68 (5), 1099-1099 2020
HARMFUL ALGAL BLOOM TOXIN MICROCYSTIN-LR EXACERBATES DEXTRAN SULFATE SODIUM INDUCED COLITIS IN A CD40 DEPENDENT MANNER
R Su, A Lad, JD Breidenbach, E Warner, C Meyers, P Dube, FK Khalaf, ...
Journal of Investigative Medicine 68 (5), 1086-1087 2020
Paraoxonase‐1 regulation of Na/K‐ATPase alpha‐1 Src signaling in Chronic Kidney Disease
FK Khalaf, CJ Mohammed, P Dube, J Connolly, A Kleinhenz, D Malhotra, ...
The FASEB Journal 34 (S1), 1-1 2020
Regulation of Renal Inflammation in Chronic Kidney Disease
FK Khalaf
The University of Toledo 2020
Paraoxonase-1 Regulation of Cardiac Inflammation and Fibrosis in Dahl Salt-Sensitive Model of Chronic Kidney Disease
P Dube, F Khalaf, A DeRiso, C Mohammed, D Battepati, AL Kleinhenz, ...
Circulation 140 (Suppl_1), A13852-A13852 2019
CARDIOPROTECTIVE EFFECTS OF PARAOXANASE 3 IN A DAHL SALT-SENSITIVE RAT MODEL OF CHRONIC KIDNEY DISEASE
P Dube, C Mohammed, F Khalaf, A DeRiso, I Tassavvor, D Battepatti, ...
JOURNAL OF INVESTIGATIVE MEDICINE 67 (5), 866-866 2019
TARGETED DISRUPTION OF NA/K-ATPASE-SRC SIGNALING CASCADE SIGNIFICANTLY REDUCES RENAL INFLAMMATION AND OXIDATIVE STRESS FOLLOWING 5/6TH PARTIAL NEPHRECTOMY
FK Khalaf, P Dube, A Kleinhenz, D Malhotra, A Gohara, C Drummond, ...
JOURNAL OF INVESTIGATIVE MEDICINE 67 (5), 920-920 2019
PARAOXANASE 1 DELETION LEADS TO INCREASED CARDIAC REMODELING AND CARDIAC FIBROSIS IN A DAHL SALT-SENSITIVE RAT MODEL OF CHRONIC KIDNEY DISEASE
P Dube, FK Khalaf, C Mohammed, A DeRiso, D Battepatti, T Sarsour, ...
JOURNAL OF INVESTIGATIVE MEDICINE 67 (5), 866-866 2019
Evidence of hepatotoxicity following chronic low dose exposure to microcystin-lr in a murine model of non-alcoholic fatty liver disease
AC Lad, A Spegele, A Kleinhenz, FK Khalaf, S Zhang, R Su, D Malhotra, ...
Journal of Investigative Medicine 66 (4), 824-824 2018
CARDTIOTONIC STEROIDS MEDIATE INFLAMMATION IN RENAL EPITHELIUM VIA THE NA/K-ATPASE ALPHA-1-SRC KINASE SIGNALING PATHWAY
FK Khalaf, J Tian, D Malhotra, Z Xie, D Kennedy
JOURNAL OF INVESTIGATIVE MEDICINE 65 (4), 851-852 2017
Cardiotonic Steroids Promote Renal Fibrosis and Dysfunction via NaK-ATPase Profibrotic Signaling in Heart Failure
X Fan, FK Khalaf, Y Chen, A Guggilam, A Kleinhenz, JB Lingrel, J Tian, ...
Circulation 134 (suppl_1), A17100-A17100"
"Molecular Medicine Track Representative, Council of Biomedical Graduate Student, University of Toledo College of Medicine and Life Science
Planning Committee: University of Toledo Council of Biomedical Graduate Students Research Forum
Planning Committee: University of Toledo Council of Biomedical Graduate Students Career Forum
Community Medicine Project Volunteer: Data collection for research project on endemic diseases in ALHUSEINIA region, for a research that was conducted in conjunction with Community Medicine Department Head in the College of Medicine/ University of Kufa, Iraq
Curriculum Implementation Committee: University of Kufa, College of Medicine Problem Based learning. This program was supervised by a guest professor from the University of Sydney, Australia

Associate Dean for Academic Affairs, College of Medicine, University of Alkafeel, Najaf 54001, Iraq.
Director of research and scientific affairs Department, University of Alkafeel, Najaf 54001, Iraq."